Endocrine Abstracts

Vandetenib has been used as novel treatment of locally invasive medullary carcinoma of thyroid. We report the use of Vandetenib in a paediatric patient with inoperable medullary carcinoma of thyroid gland. Our patient presented to the dental surgeons at age 12 years with tongue and lip swellings. Biopsy demonstrated mucosal neuromas suggestive of MEN2B. He was clinically euthyroid but had a firm goitre. Ultrasound showed a large heterogenous thyroid mass encasing the common ca...

Introduction: Thyroid cancers are the most common endocrine cancer among children, accounting for 0.5–3% of all childhood malignancies. Thyroid carcinogenesis is well established in Multiple Endocrine Neoplasia syndromes type 2, and may present with medullary thyroid cancer at young age. However, with the advancement of genetics, several other syndromes need to be considered which may lead to non-medullary thyroid cancers including DICER1 tumour predispos...